Presenting on the topic of “Deduction of novel phenotypes and disease mechanisms in uropathogenic E.coli using comparative evolutionary analysis” is our featured speaker Dr Swaine Chen, Senior Investigator,NUS, Genome Insititute of Singapore. He will be at Drug Discovery World Asia 2012, part of a series of conferences at the 5th Annual BioPharma Asia Convention 2012, held at Marina Bay Sands, Singapore.
Topics that he will be speaking on include:
1. Analysing a case study to making use of increased DNA sequence availability
2. Effective translation of sequence data in silico into new mechanistic insights in vivo using the FimH protein
3. Advantages of in silico evolutionary approaches for identification of in vivo phenotypes
A brief introduction on Dr Chen:
Dr Swaine Chen received his Ph.D. in Developmental Biology and an M.D. from Stanford University in 2004. He became interested in applying computational tools to infectious diseases during his post-doc in the lab of Scott Hultgren, Ph.D. at Washington University. Since 2010, he has been a Senior Research Scientist at the Genome Institute of Singapore and an Assistant Professor at the National University of Singapore in the Department of Medicine, doing research on new computational methods for probing host-pathogen interactions. By focusing on evolutionary methods, the pathways most relevant for pathogen survival and thus most interesting from a therapeutic perspective may be identified. He has worked specifically on E. coli that cause urinary tract infections, but the computational methods are easily generalized to other infectious diseases.