As discussed , shared and spoken by Sreehari Babu , Chemical Profiling of Novartis Pharma , there are techniques in overcoming solubility & stability in early drug development. Drugs are potentially discovered when the lead compound has been identified.
He also stated that , to improve the success rate of molecular process , a better improved and advanced technologies are needed to help in the progress. He added that there are many aspects of drug discovery and most of them are focused on the regulatory requirements of the drugs itself.
Earlier on he mention a little bit of insights about the clinical trials that usual takes place , as well as the steps that are needed for drug discovery.