Cell culture shows new class of proteins that prohibit HIV infection


Cell culture has no doubt changed the face of biologic R&D over the past 30 years and again, cell culture has proven the vital role its play by allowing scientists from Yale Cancer Center to discover how a new class of proteins inhibit HIV infection in cells, as discussed in a recent article in the online edition of the Journal of Virology.

This could pave the way for our understanding of the HIV virus and could allow for new strategies in the treatment and prevention of HIV infection and AIDS.

The team at Yale, were able to isolate six 43- and 44-amino acid proteins that inhibited cell-surface and total expression of an essential HIV receptor and were able to block HIV infection in these laboratory cell cultures.

The proteins were modeled after a protein from a papillomavirus that causes warts in cows. This bovine papillomavirus is related to the human papillomaviruses that cause cervical cancer and some head and neck cancers.

To learn more about the power and tools provided by cell culture attend the Cell Culture World Congress USA in which leading bio-manufacturers and drug developers will discuss the role of cell culture processes and technologies in developing more effective biologic drugs and increasing efficiency for R&D.

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