Top tools for integrating fermentation and DSP

Prof Tichener-Hooker, UCL, fermentation, DSP, ultra scale-down, cell culture, mammalian cell

This is the question posed by Prof. Nigel Titchener-Hooker, Head of Department and Director, The Advanced Centre for Biochemical Engineering, University College London when he spoke at the 2012  Cell Culture World Congress . Nigel went on to explore the whether operating cell culture and DSP independently results in below optimal overall outputs, and the possibility of integration improving this situation.  He also highlighted  the application of ultra scale-down (USD) tools for the characterisation of the early stages of mammalian cell processes with an emphasis on understanding how USP changes impact later levels of purification and resolution.

He completed his presentation by outlining possible strategies to dovetail the early stages of processing to reduce process complexity whilst minimising the burden of contaminants and impurities

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