Lessons learnt from unboiling an egg – Drug discovery

Scientist from UCI has recently published a study which shows methods to unboiling an egg. The 3D structure of a protein is essential in achieving its biological function. Typically, boiling a hen egg is typically used to illustrate the fragility of proteins three dimension structure and Gibbs free energy. This process is entropically driven and seemingly irreversible.

Discovery of regaining protein structure upon introduction of heat is a significant breakthrough in human knowledge and history. These sensitive biologic substances are very susceptible to environmental changes, ranging from temperature, pH, ionic concentration and other protein-protein interaction. By learning ways in recovering protein structures from what thought as irreversible aggregation process, it will definitely help researchers and manufacturers in the drug discovery field to produce a higher yield and leading to cost saving from recovering denatured proteins.

New discovery is made everyday – what else can we expect from this vibrant biopharma and drug discover field? Learn more about the latest research and manufacturing techniques & solutions by joining us at BioPharma Asia this March. Hope to see you in Singapore this March!

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