In Situ Monitoring of CHO Cell Culture Medium Using Near-Infrared Spectroscopy

In today’s white paper discussion, we delve deeper in Near Infrared (NIR) Spectroscopy and explore its capabilities for in-situ monitoring of CHO Cell Culture Medium. Building from this article, Metrohm Singapore explores how NIR technology can be further exploited for raw material identification on 24 March, Onfloor Seminar 2 at the BioPharma Asia Convention 2015.


Near-infrared (NIR) Spectroscopy is a well known analytical technique based on absorption measured in the near-infrared region of the electromagnetic spectrum, between the visible and the mid infrared. Such technology has been used by the bioprocessing industry since the early 1990s for ex situ analysis, but it has potential for in situ bioprocess monitoring. 

In efforts to maximise antibody production yield, it is important to monitor a bioreactor in situ during the CHO cell culture for effective control and optimisation of nutrient levels and ammonia production. 


Download the white paper over here.

To learn more about this product, log on to or visit Metrohm Singapore at the BioPharma Asia Convention 2015’s Onfloor Seminar Day 1 (24 March 2015) and hear Wims Guns, Chief Sales Officer share his insights on Raw Material Identification in under 30 seconds.

To register for the BioPharma Asia Convention 2015, click on this link.