Dr Jaap Boelens, Pediatric Oncologist at the University of Utrecht has also been working on developing multiple treatments using cord blood. One of which involves using cord blood transplants to improve the outcomes of an immunotherapy (Dendritic Cell Vaccination) which will go into the clinic later this year. He will be discussing his findings at the Cord Blood World Europe Congress in London on 20 – 21 May.
Like CAR-T therapies, cancer vaccines attempt to harness immune cells to fight cancer. Vaccines focus on dendritic cells, the immune system’s most powerful antigen receptors. It has been noted that while much of the immunotherapy research so far has been in blood cancers, there is evidence that these approaches also may be effective in solid tumours, even the deadliest and least-treatable solid cancers, like pancreatic cancer.
He is also working on multiple international collaborative studies (CIBMTR, Duke University, Minnesota, EBMT) on a treatment for lysosomal storage disease, a group of rare metabolic disorders, and has found cord blood to be the preferable treatment in these cases, resulting in a high impact paper.
Cord Blood Transplantation in treatment of Lysosomal Storage diseases
Involved multiple international collaborative studies over the last decade (CIBMTR, Duke University, Minnesota, EBMT) which has resulted in multiple manuscripts including some high impact papers (see pubmed). The main conclusions are:
Cord Blood is preferred cell source in lysosomal storage diseases because:
- prompt availability (no delay in treatment which prevents disease progression)
- highest probability on full donor chimerism resulting in highest enzym levels associated with best long term outcome
Current survival rates of patients with LSDs transplanted with unrelated-CB is over 95%
You can also watch an excellent video on using cord blood to optimise the effect of adjuvant immuno-therapies aiming to get better disease control at http://bit.ly/1ch6ANi.
In the video you will see predictable immune reconstitutions.
- Individualizing the conditioning we can predict immune reconstitution resulting in better suvival chances.
- With a better predictable immune reconstitution we also optimize the effect of adjuvant immuno-therapies aiming to get better disease control
To better understand Dr Boelens ‘ findings, register your attendance to the Cord Blood World Europe Congress, 20-21 May in London.