CIRM blog

Meeting the scientists who are turning their daughter’s cells into a research tool

There’s nothing like a face-to-face meeting to really get to know someone. And when the life of someone you love is in the hands of that person, then it’s a meeting that comes packed with emotion and importance. Last week Gay and Steve Grossman got to meet the people who are working with their daughter Lilly’s stem cells. Lilly was …

CIRM

Patient Advocate Leads Drive to Add Rare Diseases to CIRM’s Stem Cell Bank

November 1, 2016 Oakland, CA – Christina Waters is a rare kind of person: creative, compassionate, and committed to creating change. Now she is using those rare talents to help children battling rare diseases. She is helping add blood and skin samples from these children to be turned into stem cells and used as a resource for researchers to better understand …

HELM

HELM for Antibody Registration

Roche’s Pharmaceutical Research and Early Development (pRED) informatics team has adopted the Pistoia Alliance’s Hierarchical Editing Language for Macromolecules (HELM) as a fundamental building block of their antibody registration tool. As a result, the HELM notation and the HELM Antibody Editor (HAbE) are being rolled out throughout Roche’s bio-therapeutics group (“Large Molecule Research”) to improve the speed, accuracy and effectiveness …

HELM

HELM for Bioregistration

GSK will be making use of the Pistoia Alliance’s Hierarchical Editing Language for Macromolecules (HELM) notation to represent therapeutic large molecules in its bio-registration system, facilitated by the deployment of Dassault Systèmes BIOVIA’s Biological Registration solution. GSK scientists at sites around the world will use the system. Molecular Structure Exchange Across the industry there is a need for an advanced …

Pistoia Alliance

Ontologies Guidelines for Best Practice

By Pistoia Alliance Ontologies Mapping Project team Background These guidelines for best practice support the application and mapping of ontologies in the life sciences as part of the Pistoia Alliance Ontologies Mapping project which creates better tools and services for mapping ontologies to facilitate their exploitation. Ontologies can include hierarchical relationships; taxonomies; classifications and/or vocabularies which are becoming increasingly important for support of …

Parexel whitepaper

Three steps for filling the real- world evidence gaps

By Matthew Gordon and Kim Maguire-Wright, PAREXEL® INTERNATIONAL Today, payers and other stakeholders are demanding more (and more robust) real-world evidence (RWE) of a drug’s effectiveness and benefits. It’s understood that randomized clinical trials (RCTs), designed for regulatory approval, don’t provide a true picture of what happens in the real world. The Catch-22 is that payers would like RWE before they place a product on a formulary, …

Rare diseases

Sharing the mission to conquer rare diseases

Closer collaboration between pharmaceutical companies and patient organizations will accelerate drug development At an ever-quickening pace, biopharmaceutical companies and patient advocacy groups are banding together to hasten development of new drugs for rare diseases. Advocacy groups rely on their partners for financial and scientific support while providing access to repositories of patient data – the key to understanding rare diseases …

Diagnosis in neurosurgery

Remote intra-operative diagnosis in neurosurgery

Graham McHardy CSci FIBMS Department of Pathology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK   The introduction of digital slide scanning for remote reporting has restored an important service for patient healthcare at a Scottish hospital Telepathology is the process of digitising histological images for transmission electronically to remote centres, often for the purposes of diagnosis. Some telepathology systems employ robotic microscopes, which can be controlled remotely in order …

Cell Culture World Congress 2016 interview’s Herve Broly, Vice President Biotech Process Development, Merck Serono SA

Ahead of the Cell Culture World Congress 2016, we spoke to Herve Broly, Vice President Biotech Process Development, Merck Serono SA. Herve addresses what he believes to be the biggest achievements within the industry over the past year and lets us know what we can expect from his participation in Munich next February. 1. What do you think have been …