Download White Paper – Fed-Batch Cell Culture Process Development

CHO cell lines usually adopt the Fed-Batch approach as a primary method to manufacture therapeutic recombinant protein products. Process development for this method has been usually on how best to support high-cell density cultures that are necessary to achieve high product titres production. The issue however has always been the high nutritional demands required. If there is a lack of …

cell culture

Synthetic Biology: The Future of Cell Culture eBook

Cell culture biologics production is expensive when compared to small molecule development, with a large infrastructure of cell culture-based bioreactors to maintain prior to even generating a product. Likewise, the amount of quality control and care that must be placed into cell line and media development to reduce waste products (among other vital functions) often significantly impacts the time it …

Download White Paper : Single Use Technology specifically designed for microbial fermentation

Single Use Technology is pretty much the one of the most talked about trend in the BioPharmaceutical Space. Within a doubt, this is one topic that has been constantly asked for by our attendees across the BioPharma Asia Pacific events. As we move quickly into the next phase for the BioPharma Asia Convention 2015, we look at some of the …

Download: Quality by Design: Design Space and Scaling-Up Limitations

Merck Serono’s Thomas Solacroup joined us at the 4th Annual Cell Culture World Congress with a presentation on ‘Quality by Design: Design Space and Scaling-Up Limitations.’ In his talk, Thomas explored the Quality by Design elements and the benefits and limitations of applying this approach. His slides are available for free download below. Download Thomas Solacroup’s presentation slides here By downloading …

Download: Statistical tools in Bioprocess Development, Scale-up and Transfer

Sasa Stojkovic, Global Tech Transfer Manager at Sandoz Biopharmaceuticals joined us at the 4th Annual Cell Culture World Congress to present on ‘Exploring the capabilities of statistical tools in Bioprocess Development, Scale-up and Transfer.’ The talk included an overview of bioprocess development with a case study around designing the bioprocess in development, and scaling it up to production. Sasa kindly …

How is the post monoclonal antibodies (mAb) world going to develop in the future of biologics?

  As the pharma industry moves into the future of biologics production what challenges will they be facing? The field of biologics is currently on the brink of a new era of high tech drugs. These new drugs have been engineered to be more efficacious than typical mAbs by having a more targeted structure (i.e. antibody drug conjugates). Recently Amgen …

Download: Cell Line Development

ESACT’s Hansjörg Hauser gave a presentation at this year’s Cell Culture World Congress exploring the key stages in Cell Line Development for biotherapeutic manufacturing. Illustrated by experiments from the Dagmar Worth laboratory, his slides offer a fantastic overview of the process and key considerations. They are available for free download below: Download Hansjörg Hauser’s presentation slides By downloading these slides you …

Continuous integrated upstream and downstream processes: a viable option for the future of big pharma?

Is a continuous upstream and downstream process a viable option for the future? Integrated upstream and downstream technology seems to be the ‘holy grail’ of what can be expected for the future of biosimilar drug extraction. Industry pharma leaders such as Genzyme, GE Healthcare, and Novo Nordisk and CMO companies such as Gallus and Rentschler are all working on pushing the …

Download: Improving Cell Line Development utilising the CHO Genome Sequence

Colin Clarke from Dublin City University gave an insightful presentation at this year’s Cell Culture World Congress, on ‘Improving Cell Line Development utilising the CHO Genome Sequence.’ He explored implications of the CHO cell post-genomic era and how this information can aid cell line development. Colin kindly agreed to share his slides, which are now available for free download below. …