Download White Paper: A novel bispecific antibody, HD105, targeting VEGF and Dll4, inhibits angiogenesis and tumor growth in vivo

In this white paper,┬áSang Hoon Lee of Hanhwa Biologics discusses angiogenesis and tumour growth in vivo. Vascular endothelial growth factor (VEGF) signaling pathway have always been the method of choice for cancer treatment. However, VEGF inhibitors alone can promote tumor invasion and metastasis by increasing intratumoral hypoxia as shown in some preclinical models. Emerging reports have shown that┬áDelta-like-ligand 4 (Dll4) …