Lessons learnt from unboiling an egg – Drug discovery

Scientist from UCI has recently published a study which shows methods to unboiling an egg. The 3D structure of a protein is essential in achieving its biological function. Typically, boiling a hen egg is typically used to illustrate the fragility of proteins three dimension structure and Gibbs free energy. This process is entropically driven and seemingly irreversible. Discovery of regaining …

India’s Lupin queues up for a share of the biosimilar boom

Lupin is searching for partners to help bring it into the biosimilars market, aiming top-selling treatments with patents that are expiring soon. It already has 10 biosimilars products in development, with 5 in late-stage studies. Thus, it is looking for partners to help bring these products into the market. In addition to injectables for cancer and inflammatory disease, Lupin is …

US FDA Commissioner Margaret Hamburg met with Indian health regulators and pharma execs, saying she wanted to see more collaboration between FDA and Indian officials. However, India’s top drug regulator, G.N. Singh, the Drug Controller General of India, feels a little reluctant about adhering to all of FDA’s standards and expectations. He says that he sees some areas where the …

Ovarian cancer biomarker could predict treatment response and help prevent metastasis

A research team from Case Western Reserve University in Ohio discovered a new microRNA biomarker, miR-181a, that may identify patients who will respond better to treatment for ovarian cancer and could serve as a drug target to prevent metastasis. Ovarian tumors are more likely to be resistant to chemotherapy with high levels of miR-181a, which in turn promotes metastasis by …

Teva’s New CEO Moves Quickly on Dealmaking

Recently, pharmaceutical company Teva has been facing numerous challenges. These include expiring patents for their top drugs, strong labour opposition to plans for restructuring, conflict between the Board of Directors and Management which resulted in the CEO’s departure, and shareholder unrest. Eyal Desheh, the CFO, has said that they have to make smart deals and partnerships like how Teva has …

Download Presentation: Drug discovery program based on platform technology

At the last BioPharma Asia Convention in 2013, Masato Hosoda of Interprotein Corporation gave a presentation entitled: Drug discovery program based on platform technology. click here to download the presentation Some points that this presentation explored are: INTENDD: Interprotein’s Engine for New Drug Design Solutions for small molecular drug discovery Trends in PPI based research Summary of INTENDD’s R&D activities …

Inforgraphic: Innovation in Pharma 2013

Last week saw Deloitte publish it’s fourth annual report looking at the return on investment pharmaceutical companies are seeing in their research and development projects. The report, co-produced with Thomson Reuters, looks at the current state of development pipelines in 12 top life science companies, and calculates a projected financial return for their products in the late stages of the …

Process Optimization Made Easy: Design of Experiments with Multi-Bioreactor System BIOSTAT® Qplus

Sartorius Stedim is a sponsor at 6th Annual BioPharma Asia Convention 2013. In her whitepaper, Sartorius Stedim reveals the successful use of a BIOSTAT® Qplus six-fold system for the optimization of recombinant protein expression via DoE. The experimental procedure began with a screening for the identification of variables with a major effect on the space-time yield. The design was then …